The Influence of Paternal Preconception Health on Children

Almost everyone acknowledges the importance of a woman’s health status and diet both before and during pregnancy. But not enough attention is paid to paternal health. Diet and the health status of fathers are important as well.

For example, one study showed that if a father experienced food scarcity during the years preceding puberty, his children had a 58% lower risk of dying of heart disease as adults. On the other hand, a study showed that the opposite was true – too much food and overeating resulted in a four-fold increased risk of mortality due to diabetes in grandchildren. The effect is multigenerational.[1]

The impact is not just based on how much future dads eat, but also which foods are consumed. A study of father rats showed that after 12 weeks of eating a high-fat diet, newborn daughter rats had a 30% reduction in pancreatic beta cell mass. Beta cells produce insulin. When those daughter rats became adults, they had a higher risk of glucose intolerance and lower plasma insulin levels.[2] Birthweight is lower for babies if the father has diabetes and/or eats fast food frequently.[3]

Additionally, data from over 3000 families showed that the father’s weight at conception had a significant influence on the weight of his children after factoring in the weight of the mother. Paternal obesity can also negatively impact neurological development. Researchers looked at data for 3759 single-birth children and 1062 twins and their parents. The risk of impaired social functioning, which includes issues like avoidance of interpersonal relationships and social isolation, increased if fathers were obese; and having two obese parents increased the likelihood of failing for several domains, including fine motor, personal-social, and problem solving.[4]

The mechanisms of action are known. Small RNA molecules in sperm, referred to as mitochondrial tRNA fragments, influence the inheritance of health traits through gene regulation.[5]

The bottom line: A father’s health pre-conception matters and has a profound influence on the health and life of his child. Today, most Americans are overweight and unhealthy, and getting fatter and sicker throughout their lifetimes. This is resulting in generations of increasingly unhealthy people who not only create a financial burden for all of us due to their increased healthcare needs, but also diminished quality of life and reduced lifespan for them.


[1] Kaati G, Bygren LO, Edvinsson S. "Cardiovascular and diabetes mortality determined by nutrition during parents and grandparents’ slow growth period." Eur J Hum Genet 2022 Oct;10:682-688
[2] De Castro Barbasa T, Ingerslev LR, Alm PS et al. "High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring." Molec Metab 2016 mar;5(3):184-197
[3] Moss J, Harris K. "Impact of maternal and paternal preconception health on birth outcomes using prospective couples' data in Add Health."
Arch Gynecol Obstet. 2015 Feb;291(2):287-98.
[4] McPherson N, Fullston T, Aitken R, Lane M. "Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring." Ann Nutr Metab. 2014;64(3–4):231–238
[5] Tomar A, Gomez-Velazquez M, Gerlini R et al. "Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs." Nature 2024 Jun;630:720-727
Wellness Forum Health, Pam Popper




New Guidelines for Vitamin D

From the Desk of Pam Popper, President
Wellness Forum Health


In 2011, the Endocrine Society was one of the first organizations to endorse the vitamin D Hoax, which was invented by Michael Holick. He co-authored the Society’s Clinical Practice Guidelines, declaring no conflicts of interest in the article reporting these guidelines,[1] even though his book, The Vitamin D Solution, had been published just a few months prior, and he had worked as a consultant to Quest Diagnostics, which offers vitamin D tests, since 1979. In an interview, he said that industry funding "doesn’t influence me in terms of talking about the benefits of vitamin D."[2] Right, of course.

Holick’s conflicts were not limited to books and his relationship with Quest Labs. Between 2013 and 2017, he received money from drugmaker Sanofi-Aventis,[3] which makes vitamin D supplements.[4]

Endocrine Society Guidelines are important. They are used by hospitals, physicians, and commercial labs including Quest. Due to Holick’s influence, the Society adopted Holick’s view that vitamin D deficiency was widespread in all age groups, and therefore widespread testing should be implemented. The Society also increased the target goal from 20 ng/mm to 30 ng/ml, which served to label almost 80% of the American population as vitamin D deficient. By 2016, vitamin D testing was the fifth most common lab test that qualified for Medicare reimbursement.[5] And the goal for supplementation continued to increase, with some associations and doctors setting target plasma levels at 75-100 ng/ml. This resulted in the recommendation of higher and higher doses of vitamin D.

It did not take long for health professionals who are critical thinkers to determine that there was no widespread Vitamin D deficiency, that the tests were inaccurate, and that supplementation was not only useless, but sometimes harmful. In 2015, the US Preventive Services Task Force reported that there wasn’t enough evidence to recommend routine vitamin D screening. A 2015 article in the American Journal of Medicine stated that raising plasma levels of vitamin D to 50 ng/ml could increase the risk of death.[6]

For the last 12 years, I’ve covered the vitamin D issue, writing articles and creating workshops to educate people about the hoax. Vitamin D is NOT a vitamin; it’s a hormone. The medical definition of a vitamin is a substance that the body does not produce and must be consumed in food. Vitamin D is at best useless, and in higher doses can be harmful. Lower vitamin D levels are usually a result, not the cause of health conditions, which is why hundreds of studies showed that supplementation has no effect on the prevention of or recovery from any disease.

Finally, the Endocrine Society has partially corrected its error and now advises against routine screening and supplementation for most people. Holick was not an author of these guidelines, which include these statements:
"Based on the absence of supportive clinical trial evidence, the panel suggests against routine 25(OH)D testing in the absence of established indications."
"Further research is needed to determine optimal 25(OH)D levels for specific health benefits."[7]
Additionally, the Endocrine Society no longer endorses specific definitions of vitamin D sufficiency, insufficiency, and deficiency.

The response from many disciples of the vitamin D cult is typical: They are digging in their heels. Evidence does not matter, and the demonstration of ignorance is astounding. Peter Osborne, a diplomate with the American Clinical Board of Nutrition says, "I disagree with the guidelines. Vitamin D is an essential nutrient that plays a pivotal role in multiple functions in the body. It is one of the most common deficiencies we see in the clinic."[8]

The problem is that vitamin D is NOT a nutrient – it’s a hormone produced by the body in response to sunlight. Osborne starts with an incorrect foundation for his statements. Additionally, the only way to diagnose "deficiency" is to use inaccurate tests and guidelines set by the Endocrine Society, which is why the Society changed its recommendations.

The Vitamin D Hoax shows how easy it is for one conflicted doctor to create a multi-billion-dollar industry with almost no evidence in support. It was easy to get medical societies to go along, and almost all branches of medicine readily jumped on board. Now, it’s almost impossible to get advocates to give it up. The scariest part of this is that the Vitamin D Hoax is not an isolated event. This happens regularly in medicine. Consumers MUST learn to take control of their healthcare by becoming INFORMED.  
 


[1] Holick MF, Binkley NC, Bischoff-Ferrari HA et al. "Evaluation, Treatment, and Prevention of Vitamin D Deficienecy: an Endocrine Society Clinical Practice Guideline." J Clin Endocrin Metab 2011 Jul;96(7):1911-1930
[2] Liz Sabo. The Man Who Sold America On Vitamin D – and Profited In The Process. KFF News August 20 2018 https://kffhealthnews.org/news/how-michael-holick-sold-america-on-vitamin-d-and-profited/
[3] https://openpaymentsdata.cms.gov/
[4] https://www.campaignasia.com/article/case-study-sanofi-aventis-highlights-dark-secret-in-australia/277567
[5] https://oig.hhs.gov/reports/all/2017/medicare-payments-for-clinical-diagnostic-laboratory-tests-in-2016-year-3-of-baseline-data/
[6] Taylor CL, Thomas PR, Aloia JF, Millard PS, Rosen CJ. "Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference." Am J Med 2015 Nov;128(11):1167-1170
[7] DeMay, MB, Pittas AG, Bikle DD et al. "Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline." J Clin Endocrin Met 2024 Aug;109(8):1907-1947
[8] Sina McCullough. Vitamin D Dilemma: New Guidelines Flip the Script on Sunshine Supplements. Epoch Times Sep 9 2024 https://www.theepochtimes.com/health/vitamin-d-dilemma-new-guidelines-flip-the-script-on-sunshine-supplements-5678747


Strategy


Enjoying the Journey

Writer and philosopher Robert Persig ( Zen and the Art of Motorcycle Maintenance) wrote "Mountains should be climbed with as little effort as possible and without desire. The reality of your own nature should determine the speed. If you become restless, speed up. If you become winded, slow down. You climb the mountain in an equilibrium between restlessness and exhaustion. Then, when you're no longer thinking ahead, each footstep isn't just a means to an end but a unique event in itself." 

This is some great advice to apply to our health journey! Focusing your energy on what is attainable today, on what you can realistically accomplish today, will help you see the reality of your own nature. You have your own learning curve, and you don't need to keep up with anyone else.  Don't let perfection be a roadblock in your health journey.  Developing good habits one at a time will help you develop a good mindset. "What the mind believes, the mind creates." (Melanie Fernandez, M.D.) Success does not come from what you do occasionally, it comes from what you do consistently. Mountain climbing takes strategy and practice. So does maintaining your health journey! 

Think about what is most important to you and your family. Is good health one of them? We usually create strategies for our finances, budgeting what we can afford, when can we buy a new car, etc. Creating a health promoting environment for you and your family should be part of your life strategy.  This means prioritizing learning about health, learning how to make healthy food choices, taking time to engage in the right kind of exercise, and paying attention to all the other factors that lead to optimal health. Our strategy should be to live a healthy lifestyle to old age. 

Did you know that the belief held by the medical field is that people are not willing to listen to information about diet and lifestyle and that they just want a "magic bullet" as a solution to their health issues? This is not true! I see more and more folks wanting to learn more about their health and wanting to learn the causes of their diseases. And it's not "just genetics". People love seeing the research that supports dietary changes instead of suppressing symptoms with pills and procedures. The problem is that more time is needed by doctors with patients in order to discuss and teach lifestyle changes. Doctors are incentivized and rewarded for prescribing more drugs. According to the AMA, 71% of medical students think nutrition is clinically important when they start their education. However, the average doctor has only received about 19 hours of nutrition training in medical school.

 Most people are interested in many years of healthy living and not just changing their biomarkers with a pill. If you address the totality and breadth of your diet and lifestyle, long-term health can be achieved.  


Liz







Shedding Light on Nightshade Vegetables

 

Your Wellness Lifestyle Starts Here

I come upon a lot of misinformation about a lot of things and the information regarding nightshade vegetables can be confusing. But what does the evidence say?
 Nightshade vegetables are the edible parts of flowering plants and are members of the Solanaceae (solan-acee-ay) family. The nightshade family includes over 2000 plants, most of which are not eaten as food, and some of which, such as belladonna, are poisonous.

Nightshade vegetables include white potatoes, tomatoes, eggplant, bell peppers, Goji berries, tobacco, and tomatillos. Many herbs and spices are derived from nightshades, including cayenne pepper, crushed red pepper, chili powder, and paprika. Several condiments contain nightshades, including hot sauce, ketchup, tomato-based sauces, and salsa.

Nightshade vegetables are staple foods in many cultures, and have been consumed for centuries without side effects. Despite this, some health professionals claim that nightshade vegetables are harmful for people who have certain conditions, and others think that all people should avoid them.

The subject of controversy is nitrogen-containing substances called alkaloids and glycoalkaloids, which are naturally occurring pesticides in these foods. The claim is that they increase inflammation and can cause or worsen conditions like inflammatory bowel disease, rheumatoid arthritis, and other autoimmune diseases. The fact is that many nightshade vegetables contain phytochemicals that have been shown to be anti-inflammatory, rather than pro-inflammatory, such as capsaicin.

Solanine is one of the glycoalkaloids said to be toxic, but studies in both animals and humans have shown that glycoalkaloids/solanine in potatoes are safe, even when consumed in high doses.[1] [2] Some nightshades, like eggplant, peppers, and tomatoes, do not contain any solanine.

A literature search produced no studies definitively showing that consuming nightshade vegetables causes inflammation or disease. A Google search led to newspaper stories[3] and surveys consisting of self-reported data (notoriously unreliable) by doctors who had a personal interest in the topic because they had arthritis themselves.[4]

Dr. Steven Gundry’s comments about nightshades showed up in the google search results. Dr. Gundry says that nightshades are "aptly named because the word implies danger," and that the alkaloids in nightshades "could inspire people throughout history to consider these as evil plants." Note: it’s unlikely that people throughout history knew anything about alkaloids since the technology to identify them did not exist until modern times).

On his site, Dr. Gundry says concern may be warranted because alkaloids include strychnine, caffeine, nicotine, and morphine which have drug-like effects.[5] Gundry’s article includes many statements unsupported by references, and some statements for which there are citations that are irrelevant or misreported. But by far, my favorite comment is his statement that tobacco is not the only nightshade that contains nicotine – many nightshades do. He says this may be one of the reasons why some people become addicted to nightshades and cannot stop eating them – it’s the nicotine!

The bottom line is that there is no research supporting the idea that nightshade vegetables should be avoided. However, sometimes people with conditions like arthritis sometimes identify specific foods to which they are sensitive. These sensitivities are best identified with an elimination diet, which involves eliminating all but a few foods that are well-tolerated by almost everyone and then re-introducing the other foods one at a time to see if symptoms develop. Many members of Wellness Forum Health have been helped with elimination diets, and the results are highly variable. Some people find that there are no foods to which they are sensitive, while others determine that foods that are not usually on the highly suspect list like bananas and black pepper cause problems. In the case of nightshades, few members have discovered a sensitivity to them, and most of those who have discovered a sensitivity have identified one or two foods, not the entire category.

Elimination diets are difficult and time consuming, so it’s best to adopt a health-promoting diet first, and implement an elimination diet only if symptoms do not resolve after a reasonable period of time.

Nightshades are safe to eat for most people but do be careful. According to at least one doctor, they can be addictive. One you start eating them you may not be able to stop. Maybe that's why I crave potatoes?


[1] Mensinga TT, Sips AJ, Rompelberg CJ et al. "Potato glycoalkaloids and adverse events in humans: an ascending dose study." Regul Toxicol Pharmacol 2005 Feb;41(1):66-72.
[2] Phillips BJ, Hughes JA, Phillips JC, Walters DG, Anderson D, Tahourdin CS. "A study of the toxic hazard that might be associated with the consumption of green potato tops." Food Chem Toxicol 1996 May;34(5):439-48
[3] Susannah Meadows "The Boy With a Thorn in His Joints." New York Times Feb 1 2013
[4] Childers NF, Margoles MS. "An Apparent Relation of Nightshades (Solanaceae) to Arthritis." J Neurol Orthoped Med Surg 1993;12:227-231
[5] https://gundrymd.com/nightshade-vegetables/
Pam Popper, President, Wellness Forum Health






Focus on Health


Your Wellness Lifestyle Starts Here


Today’s healthcare system is not about health. It’s about selling a never-ending series of tests, drugs, and procedures to people. “Alternative health” is about selling different tests, supplements, and procedures to people. In order to maximize sales, tests and treatments need to be marketed to the general population, with no consideration about whether or not most people are actually candidates for or can benefit from the services promoted.

I am in the middle of reading "the Myth of Normal, Trama, Illness & Healing in a Toxic Culture" by Gabor Mate (Ma-tay). He confirms what I already have learned and teach, and his insights into the state of our current healthcare system is far encompassing. He writes "I have come to believe that behind the entire epidemic of chronic afflictions, mental and physical, that beset our current moment, something is amiss in our culture itself, generating both the rash of ailments we are suffering and. crucially, the ideological blind spots that keep us from seeing our predicament clearly."

If you have attended my Emotional Eating class, you learned how trauma affects our health in body, mind, and spirit. Mate explores this area in depth, citing numerous studies going back to the 1930s. He also includes case studies from real people proving the effects of trauma experiences and disease.

In the United States, the richest country in history and the epicenter of the globalized economic system, 60 percent of adults have a chronic disorder such as high blood pressure or diabetes, and over 40 percent have two or more such conditions. Nearly 70 percent of Americans are on at least one prescription drug; more than half take two. These are the people who are stuck in the "medical mill" and have accepted their disease because "it runs in the family". 

When asked, most people state that they want to be lean and healthy. So why aren’t most people lean and healthy? One factor is misinformation – most of what people hear, read, or are told about diet, health, and medicine is either incorrect or incomplete. But even after being provided with access to accurate and complete information, many people remain overweight and unhealthy. Why? These thinking and behavior patterns are difficult to change. Most of the time we are not aware of these patterns, which results in both confusion and frustration when they have the same unwanted experience (failure to lose weight and/or improve health) again and again.

How do we recognize and change these patterns? First, we must realize the connection between body, mind, and spirit. If one of these areas is not functioning properly, it affects the others. We are a complete being. "What happens in our cells, happens in our souls".  Empower yourself to make changes and learn how to be an informed consumer when it comes to health care. 

Start with acknowledgement. Admit that you are not moving forward because of your internal dialog and perceptions, not external forces beyond your control.
Become more aware of your thought patterns and change them. Your goal is to change your outlook to one of positive expectation. Remember that for things to change, you’ve got to change. In the absence of significant internal change, things will most likely remain the same.
Figure out the things you need in order to change your outcomes and then relentlessly pursue them. This can include therapy, a support system, reading books, gaining knowledge, finding new doctors, spending less time with some people, and changing your mindset.
Notice when you are starting to resist. Then remind yourself that resistance to doing things differently is what keeps you stuck where you are.
Work on motivation. Identify the reasons you want things to be different than they are now. People with strong reasons for change are more successful in achieving almost any goal than people who have not identified specifically why they want to change. Inadequate motivation leads to failure.
Start practicing self-control. Remind yourself that you really can think differently, change your mindset, make different decisions, and have different outcomes if you choose to do so.
Evaluate yourself and take responsibility for fixing things if necessary. If 90 days from now things are still the same, figure out why and then do something about it.
Decide to live a deliberate life, not a life that happens by default. In the absence of a specific plan for yourself, including a plan for your health, you will be forced to settle for whatever happens to you by chance. Most of the time this does not work out so well. So design your life according to what you want, and then do the things necessary to have it.

Liz Fattore
Nurture Your Health
Licensed Food Over Medicine Professional

Sources: Gabor Mate, Pam Popper











 
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